李玉保

个人简介

   李玉保，博士，教授，硕士生导师，必威经理。山东省科技特派员，聊城市驴疫病防控工程技术中心主任，山东省白羽肉鸡智能养殖工程技术研究中心主要技术负责人。中国畜牧兽医学会兽医病理学分会理事，山东动物学会常务理事。

主要从事动物疫病防控、养殖环境控制及噬菌体研究，主持教育部新农科研究与改革实践项目等省级及以上教学研究项目3项，主持国家自然科学基金、科技部常规性援外、山东省自然科学基金等省部级及以上科研项目8项，主持横向课题10余项。近年来，在专业学术刊物上共发表论文100余篇，SCI收录文章26篇，出版著作3部，获山东省科技兴农奖优秀项目一等奖1项。

教学工作

主要承担动物医学本科专业《动物病理学》以及硕士研究生《动物分子病毒学与免疫学》《动物学进展》等教学工作。

研究方向

动物疫病防控、养殖环境控制及噬菌体研究。

科研项目（近五年）

1.南太平洋岛国南太平洋岛国种养技研究与示范（KY202204002），科技部常规性援外项目，200万元，2022.12-2025.11，主持

2.mtHSP60/naïve HSP60 对MSB1 细胞凋亡调节作用及分子机制（ZR2020MC175），山东省自然科学基金，10万元，2021.01-2023.12，主持

3.基于合成生物学技术，拓展禽致病性大肠杆菌噬菌体宿主谱研究（319312101-04）,必威官方网西汉姆官方畜牧学科开放课题，15.5万，2021.8-2023.3，主持

4.甲鱼高效养殖及功能性饮料技术研发与示范（2019YQ036），山东省农业产业园区提升项目，100万，2019.8-2022.8，主持

5.禽致病性大肠杆菌噬菌体分离鉴定、组合及临床应用研究（2019QYTPY011），山东省重点研发计划项目，20万，2019.1-2021.12，主持

6.噬菌体研发项目，横向课题，200万，主持

7.山东省白羽肉鸡智能养殖，横向课题，15万，主持

8.噬菌体分离鉴定及应用，横向课题，15万，主持

9.肉羊饲养管理及疾病防控，横向课题，10万，主持

代表性成果

1.Zhang X H, Zhang M, Wu J X, Li Y B, Sun J R, Tang S, Bao E D. Gingko biloba extract EGB761 alleviates heat-stress damage in chicken heart tissue by stimulating Hsp70 expression in vivo in vascular endothelial cells, British Poultry Science, 2020, 61(2): 180-187.

2.Jing Guo, Xinxin Gao, Baotao Liu, Yubao Li, Wenqiang Liu, Jianbiao Lu, Cheng Liu, Rui Xue, Xuyong Li. Mouse adaptation of the H9N2 avian influenza virus causes the downregulation of genes related to innate immune responses and ubiquitin-mediated proteolysis in mice. Med Microbiol Immunol, 2020, 209(2): 151-161.

3.Jing Guo, Yanwen Wang, Conghui Zhao, Xinxin Gao, Yaping Zhang, Jiqing Li, Mengjing Wang, Hong Zhang, Wenqiang Liu, Chao Wang, Yingju Xia, Lu Xu, Guimei He, Jinyan Shen, Xiaohong Sun, Wenting Wang, Xinyu Han, Xiaoxuan Zhang, Zhengyang Hou, Xinlin Jin, Na Peng, Yubao Li, Guohua Deng, Pengfei Cui, Qianyi Zhang, Xuyong Li & Hualan Chen. Molecular characterization, receptor binding property and replication in chickens and mice of H9N2 avian influenza viruses isolated from chickens, peafowls and wild birds in eastern China. Emerging Microbes & Infections, 2021, DOI: 10.1080/22221751.2021.1999778

4.Shicheng Zhang, Shiyu Yuan, Tianxing Yan, Gen Li, Xiaojing Hao, Defang Zhou1, Ruiqi Li, Yubao Li, Ziqiang Cheng. Serological investigation of Gyrovirus homsa1 infections in chickens in China. BMC Veterinary Research, 2022, https://doi.org/10.1186/s12917-022-03334-0

5.Genglin Guo, Zhuohao Wang, Quan Li, Yanfei Yu, Yubao Li, Zhongming Tan, Wei Zhang. Genomic characterization of Streptococcus parasuis, a close relative of Streptococcus suis and also a potential opportunistic zoonotic pathogen. BMC Genomics, 2022, 23:469

6.Leyu Hu, Tongtong Wang, Huiying Ren, Wenqiang Liu, Yubao Li, Changfa Wang*, Liangliang Li. Characterizing the Pathogenesis and Immune Response of Equine Herpesvirus 8 Infection in Lung of Mice. Animals 2022,   https://doi.org/10.3390/ani12192495

7.Xuewei Kong, Hui Wang, Genglin Guo, Pei Li, Panpan Tong, Maojun Liu, Xun Ma, Chen Dong, Yubao Li, Haiyan Zhang, Wei Zhang. Duck sewage source coliphage P762 can lyse STEC and APEC. Virus Genes, 2022, 58(5):436-447

8.Qinghai Ren, Xiaobo Wang, Qingqing Gao, Gaiqin Wang, Xiaochen Chen, Chunxue Liu, Song Gao, Yubao Li. Glycerol Monolaurate to Ameliorate Efficacy of Inactivated Pseudorabies Vaccine. Front. Vet. Sci.2022, 9:891157

9.Shengliang Cao, Wenwen Yang, Xihui Zhu, Cheng Liu, Jianbiao Lu, Zhenshu Si, Lanying Pei, Leilei Zhang, Wensi Hu, Yanlan Li, Zhiwei Wang, Zheyu Pang, Xijuan Xue, Yubao Li. Isolation and identification of the broad‑spectrum high‑efficiency phage vB_SalP_LDW16 and its therapeutic application in chickens. BMC Veterinary Research, 2022, 18:386

10.Yanwen Wang, Hong Zhang, Mengjing Wang, Jing Guo, Conghui Zhao, Pengfei Cui, Guohua Deng, Dong Chu, Jinyan Shen, Xiaohong Sun, Xinxin Gao, Yubao Li, Wenqiang Liu, Peng Peng, Xuyong Li. Genetic Analysis of a Novel H16N3 Virus Isolated from a Migratory Gull in China in 2021 and Animal Studies of Infection. Microbiology Spectrum, 2022, e0248422

11.Yanwen Wang, Mengjing Wang, Hong Zhang, Conghui Zhao, Yaping Zhang, Guimei He, Guohua Deng, Pengfei Cui, Yubao Li, Wenqiang Liu, Jinyan Shen, Xiaohong Sun, Wenting Wang, Xianying Zeng, Yanbing Li, Dong Chu, Peng Peng, Jing Guo, Hualan Chen, Xuyong. Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020. Microbiol Spectr, 2022, 10(2): e0080722

12.Tongtong Wang, Wenqiang Liu , Changfa Wang, Xuelian Ma, Muhammad Faheem Akhtar, Yubao Li, Liangliang Li. MRKNs: Gene, Functions, and Role in Disease and Infection. Front Oncol, 2022, 12: 862206

13.Tongtong Wang, Leyu Hu, Mengyuan Liu, Tianjiao Wang, Xinyao Hu, Ying Li, Wenqiang Liu, Yubao Li, Yonghui Wang, Huiying Ren, Wei Zhang, Changfa Wang, Liangliang Li. The Emergence of Viral Encephalitis in Donkeys by Equid Herpesvirus 8 in China. Front Microbiol, 2022, 13: 840754

14.Duanduan Chen, Zhiwei Wang, Shengliang Cao, Jianbiao Lu, Cheng Liu, Lingling Yang, Xusheng Du, Hui Wang, Yubao Li. Molecular characterization and functional analysis of interferon regulatory factor-4 in the Red Claw Crayfish (Cherax quadricarinatus). Aquaculture Reports, 2022, https://doi.org/10.1016/j.aqrep.2022.101456

15.Xihui Zhu, Yanlan Li, Zhiwei Wang, Zheyu Pang, Zhenshu Si, Cheng Liu, Jianbiao Lu, Shengliang Cao, Lanying Pei, Yubao Li. Antibiotic resistance of Riemerella anatipestifer and comparative analysis of antibiotic-resistance gene detection methods. Poultry science, 2022, 102(3): 102405.

16.Tianxing Yan, Manda Zhao, Yufeng Sun, Shicheng Zhang, Xianwen Zhang, Qing Liu, Yubao Li, Ziqiang Cheng. Molecular evolution analysis of three species gyroviruses in China from 2018 to 2019. Virus Research, 2023, 199058

17.Tongtong Wang, Cankun Xi, Yue Yu, Wenqiang Liu, Muhammad Faheem Akhtar, Yubao Li, Changfa Wang, Liangliang Li. Characteristics and epidemiological investigation of equid herpesvirus 8 in donkeys in Shandong, China. Archives of Virology, 2023, 168:99

18.王俊丽，李玉保，赵哲萌，路建彪，司振书，李旭勇，杨文文，唐乃栋，郑继康. 聊城地区鸡源大肠杆菌毒力基因分析，黑龙江畜牧兽医，2020，( 17) : 88－92，170

19.杨文文，李玉保，路建彪，司振书，张凯悦，管玉堂，庞喆羽，徐欣璐，孟凡达，丁宁宁. 山东省鸡源沙门氏菌的分离鉴定及毒力基因分析，中国畜牧兽医，2021,48（8）：3069-3078

20.路建彪，王顺山，王俊丽，李玉保，司振书，杨文文，庞喆羽，徐欣璐，管玉堂，孟凡达，丁宁宁. 鸡源大肠杆菌噬菌体的分离鉴定及组合应用. 黑龙江畜牧兽医，2021，20：61-65，69，154.

21.杨文文，李玉保，路建彪，司振书，王俊丽，张凯悦，管玉堂，庞喆羽，徐欣璐. 鸡源大肠杆菌携带毒力基因、血清型及与致病性相关性的研究. 中国预防兽医学报，2021，43（10）：1051-1056

22.祝希辉，庞喆羽，王志伟，裴兰英，曹胜亮，薛希娟，李玉保. 致病性大肠杆菌携带原噬菌体的预测及耐药性与毒力研究. 中国畜牧兽医，2022,49（3）：1126-1134.

23.李艳兰，祝希辉，李玉保，管玉堂，薛希娟，乔彦良. 基因工程编辑噬菌体的技术及应用，黑龙江畜牧兽医，2022，9:41-45.

24.祝希辉,薛希娟,李艳兰,李玉保. 噬菌体介导基因转移的研究进展. 黑龙江畜牧兽医，2022，6:27-31.